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- Title
Spinal cord fusion with PEG-GNRs (TexasPEG): Neurophysiological recovery in 24 hours in rats.
- Authors
C-Yoon Kim; Sikkema, William K. A.; In-Kyu Hwang; Hanseul Oh; Un Jeng Kim; Bae Hwan Lee; Tour, James M.
- Abstract
Background: The GEMINI spinal cord fusion protocol has been developed to achieve a successful cephalosomatic anastomosis. Here, for the first time, we report the effects of locally applied water-soluble, conductive PEG(polyethylene glycol)ylated graphene nanoribbons (PEG-GNRs) on neurophysiologic conduction after sharp cervical cord transection in rats. PEG-GNRs were produced by the polymerization of ethylene oxide from anion-edged graphene nanoribbons. These combine the fusogenic potential of PEG with the electrical conducting properties of the graphene nanoribbons. Methods: Laminectomy and transection of cervical spinal cord (C5) was performed on Female Sprague-Dawley (SD) rats. After applying PEG-GNR on the severed part, electrophysiological recovery of the reconstructed cervical spinal cord was confirmed by somatosensory evoked potentials (SSEPs) at 24 h after surgery. Results: While no SSEPs were detected in the control group, PEG-GNR treated group showed fast recovery of SSEPs at 24 h after the surgery. Conclusion: In this preliminary dataset, for the first time, we report the effect of a novel form of PEG with the goal of rapid reconstruction of a sharply severed spinal cord.
- Subjects
LABORATORY rats; CEPHALOSOMATIC anastomosis; SPINAL cord; POLYETHYLENE glycol; NANORIBBONS; NEUROPHYSIOLOGIC monitoring
- Publication
Surgical Neurology International, 2016, Vol 7, p1
- ISSN
2229-5097
- Publication type
Article
- DOI
10.4103/2152-7806.190475