We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Low Dose-Olanzapine-Induced Neuroleptic Malignant Syndrome in Adolescent, and Literature Review.
- Authors
Alfakeh, Sulhi A.
- Abstract
Neuroleptic malignant syndrome is a rare but potentially lethal condition associated with neuroleptic medications. It is characterized by high temperature, extrapyramidal symptoms, autonomic variability, and changes in consciousness. Although olanzapine is an atypical antipsychotic, which exhibits more affinity to serotonin receptors than to dopamine receptors, atypical antipsychotics (like olanzapine) can cause "typical and atypical" forms of neuroleptic malignant syndrome. Previous reports of neuroleptic malignant syndrome associated with olanzapine have described patients who had been previously treated with other antipsychotic medications, patients who had previous incidents of neuroleptic malignant syndrome caused by other neuroleptics, or patients treated with olanzapine and another neuroleptic. This article describes a case of neuroleptic malignant syndrome linked to olanzapine in a male adolescent, 17-year old, who had not previously been treated with antipsychotic medications. He presented in an agitated state, with acute onset of fever, catatonia for 15 days, and severe negativism, refusal to eat, mutism, and brief episodes of abrupt psychomotor agitation and aggression toward his family.
- Subjects
OLANZAPINE; NEUROLEPTIC malignant syndrome; ANTIPSYCHOTIC agents; DRUG dosage; TEENAGE boys; DOPAMINE receptors; SEROTONIN receptors; DRUG side effects
- Publication
Journal of King Abdulaziz University: Medical Sciences, 2018, Vol 25, Issue 2, p43
- ISSN
1319-1004
- Publication type
Article
- DOI
10.4197/med.25-2.5