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- Title
Anti-cancer and Anti-proliferation Activity of Ethyl Asetat Extract from Ant Nest (Myrmecodia pendans) in Burkitt’s Lymphoma Cancer Cells.
- Authors
Achmad, Harun; Sumintarti; Handayani, Hendrastuti; Sari, Melyanti
- Abstract
Burkitt’s Lymphoma is a Non-Hodgkin Lymphoma (NHL) which is a mature neoplasm of B lymphocytes and includes aggressive lymphoma. The study aims to determine the activity of anticancer and anti-proliferation of ethyl acetate fraction of ant nest plants (Myrmecodia pendans) in Burkitt’s Lymphoma cancer cells. The study was conducted in a pure laboratory experimental method using Burkitt's Lymphoma cancer cell culture. Gradual research begins with the determination, extraction and fractionation of ant nest plants, to test for proliferation barriers. The results of testing the inhibition of lymphoma burkitt cell proliferation with ethyl acetate extract treatment showed that there was inhibition of cell growth based on the concentration given, starting from the lowest concentration of 15.625 μg/mL. Likewise, the incubation time factor of 24, 48, and 72 hours showed that the longer the incubation time, the greater the inhibition of cell growth. Ant nest ethyl acetate extract has the effect of proliferation inhibition on Burkitt’s Lymphoma cells. Antiproliferation analysis of flavonoid ethyl acetate extract based on concentration and incubation time on absorption of optical density Burkitt’s Lymphoma was statistically very significant (p = 0.00).
- Subjects
BURKITT'S lymphoma; CANCER cell culture; CANCER cells; LYMPHOMAS; ETHYL acetate
- Publication
Journal of International Dental & Medical Research, 2019, Vol 12, Issue 4, p1293
- ISSN
1309-100X
- Publication type
Article