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- Title
Mouthwash Product Development Based on Ethanol Extract of White Rice Bran (Oryza sativa L.) as Antibacterial of Streptococcus mutans and Porphyromonas gingivalis.
- Authors
Marhamah; Achmad, Harun; Mardiana; Handayani, Hendrastuti; Fajriani; Amin, Asmawati; Oktawati, Sri
- Abstract
Oral health issues are being an endless problem it classified to be the highest prevalence in the world and has the extensive impact on local health, oral and systemic. Oral diseases occur due to bacterial accumulation, including the bacteria that cause dental caries (Streptococcus mutans) and causes of periodontal disease (P. gingivalis). The current scientific approach puts forward prevention such as maintaining oral hygiene by regular brushing with toothpaste and mouthwash rather than surgical intervention. However, today the use of antiseptics in mouthwash is thought to have a carcinogenic effect. So, innovation in this research is to use rice bran extract (Oryza sativa L.) which will be formulated into dosage form mouthwash. It is also based on the potential of rice bran around 2.5 million tons per year. This type of research is a laboratory experimental study with post test design only with control group design. This research is divided into 5 stages of research, making of bran extract through maceration process, the test of bran extract content, preliminary test, mouthwash formulation formulation, stability test, comparative power inhibition test. Then the measurement and data analysis using SPSS version 22.0 for windows. The statistical analysis of bran extract with concentration of 10%, 20%, 40%, 80% and 100% with positive control of ampicillin respectively showed significant difference of drag zone (p <0,05) to Streptococcus mutans (p = 0.00) and Porphyromonas gingivalis (p = 0.001). From the test results of the content, the positive bran extract contains polyphenols. Formulation of mouthwash using 10% concentration with comparative variable mouthwash A and B and negative control showed significant effect in mouthwash extract of bran at Porphyromonas gingivalis bacteria (p = 0,018) and not significant on Streptococcus mutans (p = 0,058). Mouthwash Bran extract effectively inhibits the growth of Streptococcus mutans bacteria and Porphyromonas gingivalis
- Subjects
RICE bran; STREPTOCOCCUS mutans; PORPHYROMONAS gingivalis; RICE; ORAL hygiene products; MOUTHWASHES
- Publication
Journal of International Dental & Medical Research, 2019, Vol 12, Issue 3, p985
- ISSN
1309-100X
- Publication type
Article