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- Title
Biofilm and antibiotic resistance profile among salmonella typhi isolated from patients with typhoid fever.
- Authors
Al-Bayati, Ali Musa Kadhim; Al-Khafaji, Noor Salman Kadhim
- Abstract
Background: Salmonella enterica serovar Typhi (Salmonella Typhi) is a Gram-negative, facultative rod-shaped bacterium belonging to the family Enterobacteriaceae. It consists of more than 2668 different serotype. It can cause the disease in both humans and animals, which are the major causative pathogens of foodborne disease outbreaks and also a public health concern all over the world. Materials and Methods: Thirty-two S. Typhi isolates were recovered from 100 blood specimens of patients suffering from fever sign. All isolates confirmed by different types of agar media and VITEC2 compact apparatus; biofilm formation was assayed by tissue culture plate (TCP) while antibiotic susceptibility performed according to CLSI-2019. Results: The results revealed that, the isolation percentage of S. Typhi were 32/100(32%) isolates, and the biofilm formation using TCP method were documented 7/32 (22.88%) isolates for each of both strong and moderate biofilm former while 18/32 (56.25%) isolates were weak biofilm former. Concern correlation of biofilm formation with antibiotic resistance, the results showed strong association between biofilm formation and resistance to antibiotic. The results of antibiotic susceptibility test showed that S. Typhi resistance for penicillins (ampicillin was 32/32 [100%] and amoxicillin-clavulanate was 32/32 [100%]); for cephalosporins (all of cefoxitin, ceftazidime, and cefotaxime were 32/32 [100%]); for monobactam (aztreonam was 26 [81.25%]); for carbapenems (imipenem was 3/32 [9.37%]); for aminoglycosides (gentamicin was 32/32 [100%] and amikacin was 28/32 [87.5%]); and for quinolones and fluoroquinolones (ciprofloxacin was 32/32 [100%] and levofloxacin was 6/32 [18.75%]). Conclusion: There is a strong correlation between biofilm formation and antibiotic resistance among S. Typhi isolated from clinical specimens.
- Subjects
DRUG resistance in bacteria; SALMONELLA typhi; SALMONELLA enterica; SALMONELLA enterica serovar Typhi; FOODBORNE diseases; TYPHOID fever; AZTREONAM; FOOD pathogens
- Publication
Drug Invention Today, 2020, Vol 13, Issue 6, p966
- ISSN
0975-7619
- Publication type
Article