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- Title
Mast cell disorders in periodontal disease.
- Authors
Cathrine, G.; Gajendran, Priya Lochana
- Abstract
The aim of the review is to give an insight into the role of mast cells (MCs) and its disorders in periodontal health and disease. MCs are mobile, bone marrow-derived, granule-containing immune cells that are found in all connective tissue and mucosal environments and the peripheral and central nervous systems. MCs are able to phagocytose, process and present antigens as effectively as macrophages. MC disorders are conditions in which MCs are either increased in number, hyper-reactive, or both. These conditions range in severity from relatively benign disorders that do not impact life span to malignant clonal diseases that progress rapidly. Recently, MCs were found in high numbers in chronically inflamed gingival tissue taken from patients with chronic marginal periodontitis. This topic will review the classification of MC disorders, provide a brief clinical description of each disorder and highlights the role of MCs in periodontal health and disease.
- Subjects
MAST cells; PERIODONTAL disease; DISEASES; PERIPHERAL nervous system; MUCOUS membranes; GINGIVA
- Publication
Drug Invention Today, 2019, Vol 11, Issue 6, p1435
- ISSN
0975-7619
- Publication type
Article