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- Title
A review on drug-induced nephrotoxicity.
- Authors
Prakash, Richa; Pavithra, D.; Praveen, D.; Chowdary, P. Ranadheer; Aanandhi, M. Vijey
- Abstract
Drug-induced nephrotoxicity (DIN), which is the toxicity in the kidneys, accounts for up to 60% of hospital-acquired acute kidney injury with considerable morbidity and mortality. Nephrotoxicity displays symptoms such as decreased urine output, fluid retention, fatigue, and nausea. One of the chemotherapeutic agents, cisplatin, is used to treat cancer in numerous treatments, and cisplatin-induced nephrotoxicity is a common side effect, affecting cancer treatment. Several other drugs such as methotrexate, vancomycin, calcineurin inhibitors, amphotericin B, and aminoglycosides may also lead to nephrotoxicity. Anticancer drugs cause high toxicity leading kidney dysfunction and irreparable kidney injury. Risk for kidney injury is increased by increase in dose and duration of potentially nephrotoxic drugs. Identification of DIN and rapid dose reduction of the offending agents are critical to maximize kidney function recovery.
- Subjects
NEPHROTOXICOLOGY; HOSPITAL care; TREATMENT of acute kidney failure; TREATMENT effectiveness; VANCOMYCIN
- Publication
Drug Invention Today, 2018, Vol 10, Issue 2, p225
- ISSN
0975-7619
- Publication type
Article