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- Title
Homology modeling of fatty acid and retinoid binding (FAR) protein from the filarial nematode Acanthocheilonema viteae.
- Authors
Waghmare, Somnath; Buxi, Abhishek; Chavan, Ram
- Abstract
Two structurally novel classes of small helix-rich Fatty acid and retinoid binding (FAR) proteins are produced by parasitic nematodes. The plant and animal hosts of these parasitic nematodes have no counterparts of these proteins. FAR proteins play an active role in nematode development and survival when in contact with host tissue. Thus FAR proteins represent potential targets for new synthetic drug designing. A 3-dimensional model (3D) was designed for the Fatty acid and retinoid binding protein (178 aa) from the filarial nematode Acanthocheilonema viteae. A predicted model was constructed for the target protein using SWISS-MODEL. The constructed model was validated using protein structure checking tools for reliability. The prediction of 3D structure of a protein is a prerequisite and is also required for identifying the conformational epitopes which are essential for synthetic drug designing vaccines. Altogether, these data makes FAR protein a potentially valuable target for drug and vaccine development against filarial nematodes.
- Subjects
FATTY acid-binding proteins; RETINOIDS; FILARIASIS; ACANTHOCHEILONEMA viteae; NEMATODE development; TARGETED drug delivery; DRUG design; PROTEIN structure
- Publication
Drug Invention Today, 2014, Vol 6, Issue 1, p58
- ISSN
0975-7619
- Publication type
Article