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- Title
Molecular analysis of small tissue samples obtained via transbronchial lung biopsy using radial probe endobronchial ultrasound.
- Authors
Kim, Insu; Eom, Jung Seop; Kim, Ah rong; Lee, Chang Hun; Lee, Geewon; Jo, Eun Jung; Kim, Mi-Hyun; Mok, Jeong Ha; Lee, Kwangha; Kim, Ki Uk; Park, Hye-Kyung; Lee, Min Ki
- Abstract
Background: Radial probe endobronchial ultrasound using a guide sheath (EBUS-GS) is used to diagnose peripheral lung cancer. The aim was to identify the accuracy of molecular analysis that were performed with EBUS-GS specimens in patients with non-small cell lung cancer (NSCLC). Method: From December 2015 to September 2017, we retrospectively studied 91 patients with peripheral NSCLC who underwent surgery after EBUS-GS. Epidermal growth factor receptor (EGFR) mutational and anaplastic lymphoma kinase (ALK) translocation status obtained from surgical specimens served as the references. Results: Compared to the reference data, EGFR mutational testing of EBUS-GS specimens was in 97% agreement, and the κ coefficient was 0.931 (P< 0.001). In addition, on ALK translocation testing, the results of all 91 patients were in agreement with the reference data (concordance rate of 100%, κ coefficient 1.000; P< 0.001). Conclusion: We found that EBUS-GS could be used for molecular diagnosis, such as EGFR mutational and ALK translocation status, in patients with peripheral NSCLC.
- Subjects
LUNG biopsy; NON-small-cell lung carcinoma; LUNG cancer diagnosis; ULTRASONIC imaging; EPIDERMAL growth factor receptors
- Publication
PLoS ONE, 2019, Vol 14, Issue 2, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0212672