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- Title
Crossmatch: Alloimmunization versus unspecific agglutination reactions?
- Authors
Giger, Urs
- Abstract
As alloantibodies are expected to bind to transfused erythrocytes and lead to agglutination before free unbound alloantibodies are found in recipient plasma, it makes it even less likely that unbound alloantibodies could be detected in a crossmatch test so early posttransfusion. Such reactions are completely different from alloantibody responses induced by transfusion of canine blood with an incompatible blood type and clinicians should not automatically conclude that unspecific minor agglutination reactions are clinically relevant, as this would deter transfusion of animals in need of life-saving transfusions. Dr Barbara Kohn's group at the Clinic for Small Animals of the Freie University Berlin, Germany, recently reported on crossmatch results in (pre-) transfused dogs in I JVIM i .[1] These authors used a tube crossmatch method without canine antiglobulins to assess the potential appearance of alloantibodies posttransfusion.
- Subjects
AGGLUTINATION; ERYTHROCYTES; BLOOD groups; BLOOD agglutination; BLOOD grouping &; crossmatching
- Publication
Journal of Veterinary Internal Medicine, 2023, Vol 37, Issue 1, p8
- ISSN
0891-6640
- Publication type
Article
- DOI
10.1111/jvim.16626