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- Title
Segurança e eficácia do meloxicam associado à dipirona no tratamento da dor pós-operatória em cães.
- Authors
Biscarra Bellio, Jennifer Cristina; Baron Magalhães, Maria Angélica; Garcia Pareja, Christiane Neves; Rocha, Rita Maria Venâncio Mangrich; Michelotto Junior, Pedro Vicente; Villanova Júnior, José Ademar; Pimpão, Cláudia Turra
- Abstract
The present study aims to evaluate safety and effectiveness of a drug based on meloxicam associated to dipyrone. Animals were divided in three groups: Group 1 - meloxicam 0,1mg/kg, SID; Group 2 - meloxicam 0,1mg/kg + dipirona 25mg/kg, SID; Group 3 - meloxicam 0,1mg/kg + dipirona 25mg/kg, BID. To evaluate the clinical and laboratorial safety, 24 healthy adult dogs were treated orally for 28 consecutive days. Physical examines and blood and urine collections were made to valuate de presence of side effects of the drugs. To evaluate the effectiveness in controlling OH postoperative pain, 36 bitches were treated orally for five days. Pain assessment by the criteria of the Glasgow pain scale of canine pain and clinical exams were performed daily. In the first part of the survey, there was no laboratorial difference between groups. No clinical alteration was noticed in groups 1 and 3, but in Group 2 there were vomit and diarrhea en two animals. In the second part of the survey, there was no difference between clinical parameters and pain scores within each group, and no difference was found between groups in the physical examines. The association of meloxicam and dipyrone in dose of 0,1mg/kg + 25mg/kg, respectively, each 12 or 24 hours for up to 28 days, is safe and effectiveness in controlling post-surgical pain in dogs.
- Publication
Brazilian Journal of Veterinary Science / Revista Brasileira de Ciência Veterinária, 2015, Vol 22, Issue 3/4, p142
- ISSN
1413-0130
- Publication type
Article
- DOI
10.4322/rbcv.2016.003