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- Title
P19 Effect of Growth Hormone Replacement in the Vascular System of Adult Patients with Childhood Onset Hypopituitarism.
- Authors
Biscotto, Isabela; Costa-Hong, Valeria; Bortolotto, Luiz; Carvalho, Luciani
- Abstract
Objective: To evaluate the human recombinant growth hormone replacement (hrGHr) in the metabolic parameters and vascular system in adult patients with childhood onset hypopituitarism (COH). Patients and methods: Fifty-one adult with COH were selected for the study. They were divided into 2 groups: 1- hrGHr: 13 male, 14 female with median age 33.2 yrs, rhGHr in adult life with 7.38 yrs median time; 2 - Without hrGHr: 13 male, 11 female with 36.9 yrs median age and without hrGHr in adult life of 10.4 yrs median time. Anthropometric parameters, dual-energy X-ray absorptiometry (DEXA), lipid and glycemic profile, and structural and functional parameters of the arterial vessels (carotid intima media thickness, arterial stiffness and flow mediated dilation) were evaluated. Results: The diagnosis of obesity and overweight was higher in patients without hrGHr. Among the anthropometric characteristics, the waist-to-height ratio and diastolic blood pressure were higher in patients without replacement (p = 0.03 and p = 0.019, respectively). In the evaluation of body composition through DEXA, the Fat Mass Index among patients under hrGHr was significantly lower than in patients without hrGHr (p = 0.029). Although no statistical difference in the vascular parameters between patients with and without hrGHr, it was observed a trend towards a higher arterial stiffness in the group without replacement (p = 0.051). In the group of patients without hrGHr, arterial stiffness had a significant and positive correlation with the time without hrGHr (p = 0.038). Conclusions: These data suggest that the hrGHr in adults with COH may have protective effects on cardiovascular system.
- Publication
Artery Research, 2018, Vol 24, p85
- ISSN
1872-9312
- Publication type
Abstract
- DOI
10.1016/j.artres.2018.10.072