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- Title
Fluid absorption by proximal tubules in the absence of a colloid osmotic gradient.
- Authors
Horster, M.; Burg, M.; Potts, D.; Orloff, J.
- Abstract
The rates of fluid absorption (Jv) of isolated perfused rabbit proximal convoluted tubules bathed either in rabbit serum or in protein-free ultrafiltrates of rabbit serum were compared. No change in Jv was observed when normal serum in the bath was replaced by an ultrafiltrate prepared with membranes that nominally exclude solutes of molecular weight greater than 10,000 and 14,000. Similar results were obtained when a protein-free artificial saline buffer that had been dialyzed against rabbit serum across one of these membranes was employed as the bathing solution. It is concluded that a colloid osmotic pressure difference generated by serum protein is not required for the absorptive process. In agreement with others [1, 2], substitution for serum in the bath of protein-free ultrafiltrate prepared with membranes that nominally exclude solutes of molecular weight greater than 50,000 reduced Jv. In contrast to their results, however, addition of 6.5 g/100 ml of albumin to this ultrafiltrate did not restore Jv to control values. It is probable that unidentified factors other than protein colloid osmotic pressure were responsible for the reduction in Jv under these circumstances.
- Subjects
ABSORPTION; COLLOIDS in medicine; BLOOD proteins; ALBUMINS; MOLECULAR weights; LABORATORY rabbits
- Publication
Kidney International, 1973, Vol 4, Issue 1, p6
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.1973.74