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- Title
Parenteral Lipid Dose Restriction With Soy Oil, Not Fish Oil, Preserves Retinal Function in Neonatal Piglets.
- Authors
Lansing, Marihan; Sauvé, Yves; Dimopoulos, Ioannis; Field, Catherine J.; Suh, Miyoung; Wizzard, Pamela; Goruk, Susan; Lim, David; Muto, Mitsuru; Wales, Paul; Turner, Justine
- Abstract
<bold>Background: </bold>A dietary supply of docosahexaenoic acid (DHA) and arachidonic acid (AA) is critical for neonatal retinal development. Both are absent/minimal in parenteral nutrition (PN) using soy-oil emulsions ([SO] Intralipid®) traditionally used for neonatal intestinal failure. In contrast, fish-oil emulsions ([FO] Omegaven®) are enriched in DHA/AA. The aim of this study was to compare retinal function and fatty acid content in neonatal piglets fed PN with SO or FO.<bold>Methods: </bold>Two-5-day-old piglets were randomly allocated to SO (n = 4) or FO (n = 4), provided at equivalent doses (5g/kg/d). After 14 days of PN, retinal function was assessed by electroretinography and retinas were harvested for fatty acid content analysis. Sow-fed piglets served as a reference (REF).<bold>Results: </bold>Light flash-elicited stoppage of cone and rod dark-currents (a-waves) and the ensuing postsynaptic activation of cone and rod ON bipolar cells (b-waves) were comparable between SO and REF. Responses recorded from FO were subnormal (P <0.001) when compared with both SO and REF. Retinal DHA content was similar in both groups (FO, 14.59% vs SO, 12.22%; P = 0.32); while AA was lower in FO (FO, 6.01% vs SO, 8.21%; P = .001).<bold>Conclusion: </bold>Paradoxically, FO containing more DHA and AA did not preserve retinal function when compared with the same low dose of SO. This may be due to the reduced AA enrichment in the retina with FO treatment. Further investigation into the ideal amounts of DHA and AA for optimal neonatal retinal function is required.
- Subjects
PARENTERAL feeding; SOY oil; DOCOSAHEXAENOIC acid; ARACHIDONIC acid; RETINAL development; RETINA physiology; ANIMAL populations; ANIMALS; EMULSIONS; INTRAVENOUS fat emulsions; FATTY acids; FISH oils; PHOSPHOLIPIDS; PHOTORECEPTORS; RETINA; SWINE
- Publication
JPEN Journal of Parenteral & Enteral Nutrition, 2018, Vol 42, Issue 7, p1177
- ISSN
0148-6071
- Publication type
journal article
- DOI
10.1002/jpen.1145