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- Title
The association between the CC chemokine ligand 5-28C>G gene polymorphism and tuberculosis susceptibility.
- Authors
Hongfang Lu; Jingang Wang; Baoan Gao; Shixiong Chen; Guangming Xiang; Shaojuan Yang; Yuan Gong; Li Guan
- Abstract
Objectives: To assess the association between chemotactic chemokine (C-C motif ) ligand 5 (CCL5) -28C>G polymorphism and tuberculosis (TB) risk. Methods: PubMed, Web of Science, and WanFang were searched up to April 2015 for eligible studies on CCL5 -28C>G polymorphism. Data was extracted, and pooled odd ratios (ORs) as well as 95% confidence intervals (95% CI) were calculated. Results: Eight case-control studies were extracted from 8 articles on the polymorphism involving 1852 TB cases and 2068 controls. The results of meta-analysis showed that significant reduced risks were found for the polymorphism with the risk of TB in Asians and Arabs as follows: OR=0.12, 95% CI=0.06-0.26, p=0.000 for mutant homozygous (GG) versus wild-type homozygous (CC) for Asian descent, OR=0.14, 95% CI=0.07-0.28, p=0.000 for GG versus CC in the Arab descent. Conclusion: Our findings demonstrated that CCL5 gene -28C>G polymorphism might be a protective factor for the development of TB.
- Publication
Saudi Medical Journal, 2015, Vol 36, Issue 12, p1400
- ISSN
0379-5284
- Publication type
Article
- DOI
10.15537/smj.2015.12.12264