We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Controlled Release of Simvastatin Acid Using Cyclodextrin Inclusion System.
- Authors
YOSHINARI, Masao; MATSUZAKA, Kenichi; HASHIMOTO, Sadamitsu; ISHIHARA, Kazuyuki; INOUE, Takashi; ODA, Yutaka; IDE, Takaharu; TANAKA, Teruo
- Abstract
Simvastatin acid (SVA) has been reported to stimulate bone formation by increasing expression of BMP-2 in osteoblasts. Due to their multi-functional characteristics and bioadaptability, cyclodextrins (CDs) are capable of forming inclusion complexes with many drugs by including a whole drug molecule inside their cavity. In the present study, we prepared SVA/CD inclusion complex solutions with different pH values. These were then used to determine their SVA release behavior after coating on titanium substrates, as well as to clarify the characteristics of SVA/CD complexes per se. Results showed that the lower the pH value of the solution, the lower the release kinetics of SVA. Besides, the amount of crystalline complexes in the coatings increased with decrease in pH. These results suggested that the release rate of SVA depended on two factors: pH of the solution and concomitant crystallinity of the coating.
- Subjects
BONE growth; CYCLODEXTRINS; HYDROGEN-ion concentration; DENTAL materials; DENTISTRY
- Publication
Dental Materials Journal, 2007, Vol 26, Issue 3, p451
- ISSN
0287-4547
- Publication type
Article
- DOI
10.4012/dmj.26.451