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- Title
In vivo effects of Viscum album and probiotics against carbon tetrachloride-induced liver injury.
- Authors
Erdaş, Meltem; Akyüz, Fahrettin; Can, Betül; Özkoç, Mete; Öz, Semih; Dönmez, Dilek Burukoğlu
- Abstract
This study tested the possible protective and therapeutic effects of Viscum album extract and probiotics against carbon tetrachloride (CCl4)-induced acute/chronic liver injury. Male Wistar rats were assigned to seven groups: Control, acute CCl4, acute V. album + CCl4, acute V. album + Probiotics + CCl4, chronic CCl4, chronic CCl4 + V. album, and chronic CCl4 + V. album + Probiotics. Acute and chronic liver injuries were induced by 2 mg/kg CCl4 (i.p.) and 1 mg/kg CCl4 (i.p.), respectively. The extract and probiotics were administered daily to related groups. Serum enzyme activities, lipid profile, total protein, albumin, bilirubin, heme oxgenase-1 and 8-hydroxydeoxyguanosine levels were measured. Liver tissue sections stained with Hematoxylin-Eosin. Acute or chronic CCl4-exposure caused to significant changes in concentrations/activities of the measured parameters. The oral administration of extract and probiotics showed protective and therapeutic effects against CCl4-induced liver-injury. The supplementation of intestinal flora by the use of probiotics may enhance the efficacy of orally given therapeutic extracts.
- Subjects
LIVER injuries; PROBIOTICS; LABORATORY rats; CARBON tetrachloride; INTESTINES; TREATMENT effectiveness
- Publication
Journal of Bioenergetics & Biomembranes, 2021, Vol 53, Issue 2, p139
- ISSN
0145-479X
- Publication type
Article
- DOI
10.1007/s10863-021-09883-7