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- Title
An Osteoconductive Antibiotic Bone Eluting Putty with a Custom Polymer Matrix.
- Authors
Curley, John; Hasan, Mohammad Raquibul; Larson, Jacob; Brooks, Benjamin D.; Qianhui Liu; Jain, Tanmay; Joy, Abraham; Brooks, Amanda E.
- Abstract
With the rising tide of antibiotic resistant bacteria, extending the longevity of the current antibiotic arsenal is becoming a necessity. Developing local, controlled release antibiotic strategies, particularly for difficult to penetrate tissues such as bone, may prove to be a better alternative. Previous efforts to develop an osteoconductive local antibiotic release device for bone were created as solid molded composites; however, intimate contact with host bone was found to be critical to support host bone regrowth; thus, an osteocondconductive antibiotic releasing bone void filling putty was developed. Furthermore, a controlled releasing polymer matrix was refined using pendant-functionalized diols to provide tailorable pharmacokinetics. In vitro pharmacokinetic and bioactivity profiles were compared for a putty formulation with an analogous composition as its molded counterpart as well as four new pendant-functionalized polymers. A best-fit analysis of polymer composition in either small cylindrical disks or larger spheres revealed that the new pendant-functionalized polymers appear to release vancomycin via both diffusion and erosion regardless of the geometry of the putty. In silico simulations, a valuable technique for diffusion mediated controlled release models, will be used to confirm and optimize this property.
- Subjects
BIOMEDICAL adhesives; POLYMERS; PUTTY; ANTIBIOTICS; VANCOMYCIN
- Publication
Polymers (20734360), 2016, Vol 8, Issue 7, p247
- ISSN
2073-4360
- Publication type
Article
- DOI
10.3390/polym8070247