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- Title
EFFECT OF VITAMIN D SUPPLEMENTATION ON THIOREDOXIN BINDING PROTEIN 2 GENE EXPRESSION IN PATIENTS WITH DIABETES TYPE 2.
- Authors
Rad, Esmaeil Yousefi; Attar, Mohammad Javad Hosseinzadeh; Koohdani, Fariba; Saboor-Yaraghi, Ali Akbar; Eshraghian, Mohammad Reza; Javanbakht, Mohammad Hassan; Saboori, Somayeh; Chamari, Maryam; Zarei, Mahnaz; Djalali, Mahmoud
- Abstract
Diabetes type 2 is an oxidative stress related disease. This randomized controlled trial was done to evaluate the effect of vitamin D supplementation on thioredoxin binding protein 2 (TBP-2) gene expression in patients with type 2 diabetes. Subjects of this study consist of 28 patients with type 2 diabetes who received 100mg (4000 IU) vitamin D and 30 diabetic patients who received placebo for two months. The effect of vitamin D on gene expression of TBP-2 in PBMC cells was measured by RT-PCR at the beginning and at the end of the study. The results of this study showed no significant differences in TBP-2 gene expression between 2 groups, but a significant decrease in serum TBP-2 concentration in vitamin D receiving group at the end of supplementation. It seems that vitamin D supplementation has no effect on the TBP-2 gene expression in PBMC cells.
- Subjects
PHYSIOLOGICAL effects of vitamin D; DIETARY supplements; THIOREDOXIN; CARRIER proteins; TYPE 2 diabetes treatment; OXIDATIVE stress; GENE expression; RANDOMIZED controlled trials
- Publication
Current Topics in Nutraceutical Research, 2015, Vol 13, Issue 1, p55
- ISSN
1540-7535
- Publication type
Article