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- Title
AQUEOUS EXTRACT OF DATE FRUIT PROTECTS CA1 NEURONS AGAINST OXIDATIVE INJURY: AN ULTRASTRUCTURAL STUDY.
- Authors
Marzieh, Panahi; Majid, Asadi-Shekaari; Taj Pari, Kalantari-pour; Ali, Safavi
- Abstract
Stroke is a leading cause of mortality and morbidity in many countries. Aqueous Extract of Date Fruit (AEDF) is a potent antioxidant agent that could protect hippocampal neurons against oxidative injury. To determine whether the protected neurons by AEDF have a normal ultrastructure, hippocampal CA1 neurons were examined by electron microscopy. Male NMRI rats were fed with dose of AEDF (250 mg/kg) through stomach intubation for 2 weeks. The right middle cerebral artery was ligated for 30 min followed by 48h reperfusion. The animals were anesthetized, and their brains removed, processed and examined under a transmission electron microscope. Ischemic necrotic changes were observed in rats not pre-treated with AEDF, but pyramidal neurons ultrastructure appeared normal in rats that pre-treated with AEDF. Pretreatment of AEDF had a neuroprotective effect in ischemic brain. Antioxidant property is one of the major profiles of AEDF that is implicated in brain protection
- Subjects
CEREBROVASCULAR disease; MORTALITY; DISEASES; ANTIOXIDANTS; NEURONS; ELECTRON microscopy; REPERFUSION
- Publication
Current Topics in Nutraceutical Research, 2008, Vol 6, Issue 3, p125
- ISSN
1540-7535
- Publication type
Article