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- Title
Optimization of Automated Radiosynthesis of Gallium-68-Labeled PSMA11 with Two [ 68 Ge]Ge/[ 68 Ga]Ga Generators: Fractional Elution or Prepurification?
- Authors
Durieux, Flore; Dekyndt, Bérengère; Legrand, Jean-François; Rogeau, Antoine; Malek, Emmanuel; Semah, Franck; Odou, Pascal
- Abstract
Prostate cancer is one of the most common forms of cancer in men. An imaging technique for its diagnosis is [68Ga]-prostate-specific membrane antigen ([68Ga]Ga-PSMA-11) positron emission tomography (PET). To address the increasing demand for [68Ga]-labeled peptides and reduce the cost of radiosynthesis, it is therefore necessary to optimize the elution process of [68Ge]Ge/[68Ga]Ga generators. This study aims to identify the most effective approach for optimizing radiosynthesis using double elution in parallel of two [68Ge]Ge/[68Ga]Ga generators. Two methods have been tested: one using prepurification, and the other using fractionated elution. Five synthesis sequences were conducted using each method. The mean labeling yields for double elution with prepurification were 45.8 ± 29.4 (mean ± standard deviation) and none met the required criteria. The mean labeling yields for the fractionated double elution were 97.5 ± 1.9 (mean ± standard deviation) meeting the criteria, significantly superior to the prepurification method (p = 0.012), and similar to those of simple elution. This study showed that fractionated double elution from [68Ge]Ge/[68Ga]Ga generators produced a significantly higher labeling yield than double elution with prepurification, resulting in a larger activity recovered via radiosynthesis, thereby allowing more diagnostic tests to be performed.
- Subjects
POSITRON emission tomography; STANDARD deviations; CANCER patients; DIAGNOSIS methods
- Publication
Pharmaceuticals (14248247), 2023, Vol 16, Issue 11, p1544
- ISSN
1424-8247
- Publication type
Article
- DOI
10.3390/ph16111544