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- Title
Pharmacological Properties of Jaeumgeonbi-Tang on Redox System and Stress-Related Hormones in Chronic Subjective Dizziness: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial.
- Authors
Kim, Chan-young; Kim, Hyeong-Geug; Lee, Hye Won; Seol, In-Chan; Kim, Yoon-Sik; Choi, Hyung Il; Park, Miso S.; Yoo, Ho-Ryong
- Abstract
Jaeumgeonbi-Tang (JGT), a traditional herbal medicine, has been used to treat dizziness and vertigo in Korea and China for hundreds of years. The purpose of this study was to evaluate the pharmacological properties of JGT in chronic subjective dizziness (CSD) patients. A randomized, double-blind, parallel-group and placebo-controlled trial was performed with a total of 50 CSD patients. The patients were randomly assigned to one of two groups: JGT or placebo (n = 25 for each). All participants received the treatment (placebo or JGT, 24 g/day) for 4 weeks. We analyzed the serum levels of oxidative stressors, antioxidants, and stress hormones. Serum levels of lipid peroxidation, but not nitric oxide, were significantly decreased in the JGT group. JGT not only prevented the decline of serum total glutathione contents and total antioxidant capacity, but it also increased superoxide dismutase and catalase activities. Serum levels of stress hormones including cortisol, adrenaline, and serotonin were notably normalized by JGT treatment, but noradrenaline levels were not affected. Regarding the safety and tolerability of JGT, we found no allergic, adverse, or side effects in any of the participants. JGT showed beneficial effects on CSD patients by improving redox status and balancing psycho-emotional stress hormones.
- Subjects
SOUTH Korea; CHINA; OXIDATION-reduction reaction; OXIDATIVE stress; SEROTONIN; OXIDANT status; HYDROCORTISONE; DIZZINESS; HORMONES; SUPEROXIDE dismutase
- Publication
Pharmaceuticals (14248247), 2022, Vol 15, Issue 11, p1375
- ISSN
1424-8247
- Publication type
Article
- DOI
10.3390/ph15111375