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- Title
Clinicopathological features of colon polyps from African-Americans.
- Authors
Nouraie, Mehdi; Hosseinkhah, Fatemeh; Brim, Hassan; Zamanifekri, Behrouz; Smoot, Duane T.; Ashktorab, Hassan
- Abstract
<bold>Background and Aims: </bold>Among the ethnic groups, the age-standardized incidence rate of colorectal cancer (CRC) is highest among African-Americans. The majority of CRC arise from preexisting adenoma. It is shown that 30% of the US adult population has adenomas. The potential risk of malignant transformation in adenomas differs by specific pathologic and clinical characteristics that we aimed to study in AAs.<bold>Materials and Methods: </bold>All pathologic reports (150,000) in Howard University Hospital from 1959 to 2006 were reviewed manually. Those pathology reports compatible with the colorectal polyps were carefully reviewed and selected by a GI pathologist. All cases with cancer were then excluded from the list. Data were then entered into Microsoft Excel and checked for missing data and duplications. Differences in right-side and left-side polyps for sex, histology, and clinical symptoms were assessed by Chi-2 test.<bold>Results: </bold>A total number of 5,013 colorectal polyps were diagnosed in this period that include 47% male, with mean age (SD) of 63 (12). Half of the cases were diagnosed in 2001-2006. Tubular adenoma was the most frequent pathology (73%). The highest frequency of right-sided polyps was observed in the 1990s (56%). Left-sided polyps were younger (p < 0.0001), more hyperplasic (23 vs. 5%; p < 0.0001), and more frequent in female (56 vs. 52%; p = 0.02) compared to right-sided polyps. The frequency of right-sided adenoma significantly increases from 18% in the 1960s to 51% in the period of 2001-2006 (p < 0.0001). The most frequent symptom in both sides was GI bleeding (21%).<bold>Conclusion: </bold>There was a ratio of 8:1 for neoplastic to hyperplastic polyps in our study, which is more than what has been reported in Caucasians (7:1). Our data shows a shift in polyps from the left side to the right side of the colon in recent years. This data is consistent with the lack of a reduction in the incidence of colon cancer in African-Americans. Screening is thus very important in AA to reduce the incidence of colon cancer.
- Subjects
WASHINGTON (D.C.); POLYPS; DISEASES in African Americans; COLON cancer; ADENOMA; HOWARD University Hospital; DIAGNOSIS; PATIENTS; STATISTICS on Black people; CHI-squared test; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH funding; EVALUATION research; DISEASE incidence; COLON polyps
- Publication
Digestive Diseases & Sciences, 2010, Vol 55, Issue 5, p1442
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-010-1133-5