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- Title
Characterization with monoclonal antibodies of human lymphocytes active in natural killing and antibody-dependent cell-mediated cytotoxicity of dengue virus-infected cells.
- Authors
Kurane, I.; Hebblewaite, Diane; Ennis, F. A.
- Abstract
Non-immune human peripheral blood lymphocytes (PBL) lyse dengue virus-infected cells to a greater degree than uninfected cells. In the present study, the PBL active in lysing dengue virus- infected Raji cells are characterized using monoclonal antibodies and are compared to lymphocytes that lyse K562 cells. Leu11 + cells lyse dengue virus-infected cells and K562 cells. Leu11 - cells lyse dengue virus-infected cells, but not K562 cells. In the Leu11 + fraction, Leu11+ Leu7- cells are more active than Leu 11 + Leu7+ cells in lysing dengue virus-infected cells. T3 + cells also lyse dengue virus- infected cells, but they do not lyse K562 cells. T3+ cells lyse both target cells. These results, along with the observation that Leu 11+ cells and T3+ cells are different subsets of PBL, indicate that the PBL that are active in lysing dengue virus-infected cells are heterogeneous and are contained in Leu11 + and T3+ subsets. Leu 11 + cells are more active than T3+ cells. Leu 11+ cells are active in lysing dengue virus-infected cells by antibody-dependent cell-mediated cytotoxicity, whereas T3 + cells are not active.
- Subjects
MONOCLONAL antibodies; LYMPHOCYTES; CELL-mediated cytotoxicity; KILLER cells; CELL death; IMMUNOGLOBULINS
- Publication
Immunology, 1986, Vol 58, Issue 3, p429
- ISSN
0019-2805
- Publication type
Article