We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Penicillin derivatives are true monovalent elicitors of anaphylactic reactions.
- Authors
Guenin, R.; Schneider, C. H.
- Abstract
Conjugates carrying a single 2-carboxy-4,6-dinitrophenyl hapten and as auxiliary group various thiazolidine substituents related to penicilloyl, were prepared and studied in guinea-pig passive cutaneous anaphylaxis (PCA). Included are monohaptenic model conjugates with discrete hydrocarbon auxiliary groups. One of the conjugates with the 3-formyl-2,2-dimethyl-1,3-thiazolidine-(4S)-oyl auxiliary group, characterized by the blocked chemical reactivity of the thiazolidine, was an anaphylactogen. This rules out formation of oligohaptenic antigens via chemical conjugation as a step in the PCA reactions observed. Rather, the non-covalent interactions of the auxiliary group, which has very strict structural requirements net yet mapped out in full, are necessary. Data from the model conjugates show that planar ring structures in conjunction with unsubstituted carboxyl groups constitute effective auxiliary groups. Benzylpenicilloyl antigens may act as monovalent elicitors of immediate reactions when the antibody population is predominantly directed against the benzyl side-chain. Under these conditions the benzyl residue is expexted to serve as the haptenic part and the thiazolidine moiety as the auxiliary group.
- Subjects
PENICILLIN; ANAPHYLAXIS; HYDROCARBONS; CHEMICAL reactions; ANTIGENS; MOLECULAR weights
- Publication
Immunology, 1984, Vol 52, Issue 1, p189
- ISSN
0019-2805
- Publication type
Article