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- Title
Changes in renal dimensions evaluated by magnetic resonance imaging and ultrasonography during long-term ciclosporin-A treatment.
- Authors
Grøn, M. C.; Hanefelt Kristensen, D.; Cibulskyte, D.; Hørlyck, A.; Kaalund, H.; Hansen, H. E.; Madsen, M.; Pedersen, Michael; J. Mortensen; Grøn, M C; Hørlyck, A; Pedersen, M; Mortensen, J
- Abstract
<bold>Purpose: </bold>To investigate changes in renal dimensions during long-term treatment with ciclosporin-A (CsA). <bold>Material and Methods: </bold>Five mini-Göttingen pigs were treated with CsA (10 mg kg(-1) day(-1)) for 6 months; 3 untreated animals served as controls. Renal length was measured by magnetic resonance imaging (MRI) and ultrasonography (US); renal volume by MRI. Examinations were performed at baseline (0 weeks) and after the start of CsA treatment at intervals of 5 weeks (5-25 weeks). <bold>Results: </bold>Comparison of baseline and end-point data (0 weeks vs. 25 weeks) revealed a statistically significant increase in renal volume in CsA-treated animals (87.1 cm3 vs. 55.9 cm3, P=0.002). Renal volume remained unchanged in the control group. A significant increase in renal length was found both in the CsA-treated pigs (MRI: 96 mm vs. 84 mm, P<0.001; US: 94 mm vs. 81 mm, P<0.001) and in the control group (MRI: 97 mm vs. 85 mm, P<0.001; US: 89 mm vs. 81 mm, P=0.018). No difference was found between MRI and US measurements based on 40 paired units (MRI variance: 2.4-30.3% and US variance: -5.1-40.6%, P=0.133). <bold>Conclusion: </bold>During long-term CsA treatment, renal volume increases in mini-pigs, but there is no correlation between the increase in volume and the increase in length in this pig model.
- Subjects
RENAL artery; MAGNETIC resonance imaging; DIAGNOSTIC imaging; IMMUNOSUPPRESSION; TRANSPLANTATION of organs, tissues, etc.; NEPHROTOXICOLOGY; HYPERTENSION; HEMODYNAMICS; BIOCHEMISTRY
- Publication
Acta Radiologica, 2006, Vol 47, Issue 1, p58
- ISSN
0284-1851
- Publication type
journal article
- DOI
10.1080/02841850500406829