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- Title
Cerebral Blood Flow Measurement Using fMRI and PET: A Cross-Validation Study.
- Authors
Chen, Jean J.; Wieckowska, Marguerite; Meyer, Ernst; Pike, G. Bruce
- Abstract
An important aspect of functional magnetic resonance imaging (fMRI) is the study of brain hemodynamics, and MR arterial spin labeling (ASL) perfusion imaging has gained wide acceptance as a robust and noninvasive technique. However, the cerebral blood flow (CBF) measurements obtained with ASL fMRI have not been fully validated, particularly during global CBF modulations. We present a comparison of cerebral blood flow changes (ΔCBF) measured using a flow-sensitive alternating inversion recovery (FAIR) ASL perfusion method to those obtained using H215O PET, which is the current gold standard for in vivo imaging of CBF. To study regional and global CBF changes, a group of 10 healthy volunteers were imaged under identical experimental conditions during presentation of 5 levels of visual stimulation and one level of hypercapnia. The CBF changes were compared using 3 types of region-of-interest (ROI) masks. FAIR measurements of CBF changes were found to be slightly lower than those measured with PET (average ?CBF of 21.5 ± 8.2% for FAIR versus 28.2 ± 12.8% for PET at maximum stimulation intensity). Nonetheless, there was a strong correlation between measurements of the two modalities. Finally, a t-test comparison of the slopes of the linear fits of PET versus ASL ΔCBF for all 3 ROI types indicated no significant difference from unity (P > .05).
- Subjects
IMAGE reconstruction; BLOOD flow measurement; MAGNETIC resonance imaging; MEDICAL imaging systems; BRAIN imaging
- Publication
International Journal of Biomedical Imaging, 2008, p1
- ISSN
1687-4188
- Publication type
Article
- DOI
10.1155/2008/516359