We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Neuropeptide Y Leu7Pro Polymorphism Associated With the Metabolic Syndrome and Its Features in Patients With Coronary Artery Disease.
- Authors
Masoudi-Kazemabad, Ali; Jamialahmadi, Khadijeh; Moohebati, Mohsen; Mojarrad, Majid; Manshadi, Raheleh Dehghan; Akhlaghi, Saeed; Ferns, Gordon A.; Ghayour-Mobarhan, Majid
- Abstract
The metabolic syndrome (MetS) is characterized by constellation of clinical and biochemical features that increase the risk of cardiovascular disease. Neuropeptide Y (NPY) is a neurotransmitter and enhances the development of obesity and other aspects of MetS. We determined the association between NPY Leu7Pro polymorphism and features of MetS in Iranian patients with coronary artery disease (CAD). A total of 550 patients with CAD including individuals with (n = 184) and without MetS (n = 366) were genotyped by polymerase chain reaction–restriction fragment length polymorphism. A significantly higher frequency of the Leu7Pro polymorphism was found in patients with MetS compared with the non-MetS patients (P = .001). Furthermore, there was a significant difference in Pro7 frequency between diabetics versus nondiabetics (P = .005), dyslipidemic versus nondyslipidemic (P = .04), and obese versus nonobese (P = .001) in this population. Leu7Pro polymorphism is associated with the MetS in patients with CAD.
- Subjects
IRAN; ANALYSIS of variance; ANTHROPOMETRY; CHI-squared test; CORONARY disease; GENES; GENETIC polymorphisms; LEUCINE; LIPIDS; NEUROPEPTIDES; POLYMERASE chain reaction; PROLINE; RESEARCH funding; STATISTICS; METABOLIC syndrome; CROSS-sectional method; DATA analysis software; DESCRIPTIVE statistics
- Publication
Angiology, 2013, Vol 64, Issue 1, p40
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319711435149