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- Title
Genetic variation of TLR3 gene is associated with the outcome of hepatitis b infection in mauritanian patients: case control study.
- Authors
Soumbara, Tetou; Bonnet, Crystel; Hamed, Cheikh Tijani; Veten, Fatimetou; Hemeyine, Mohamed; Fall-Malick, F-Zahra; El Yezid, Mohamed Mahmoud; Diallo, Aichetou; Mounah, Moustapha Mouhamedou; Houmeida, Ahmed
- Abstract
Background: Toll-Like receptors (TLRs) play an important role in the immune response during hepatitis B virus (HBV) infection. In this study, we evaluated the association between two SNP variants (TLR3 rs3775290 and TLR4 rs4986790) and susceptibility to chronic HBV infection in Mauritania. Subjects and methods: : A total of 188 subjects were recruited for this study: 102 chronically infected patients and 86 individuals with spontaneously resolved HBV infection who were considered controls. Targeted PCR products were sequenced using Sanger sequencing. Results: We found that TLR3 rs3775290 was significantly more frequent in patients with chronic HBV than in the control population (p = 0.03). However, no association was found between the TLR4 rs3775290 polymorphism and chronic infection. Conclusion: Our results suggest that the TLR3 rs3775290 polymorphism may be a risk factor for susceptibility to chronic HBV infection in the Mauritanian population.
- Subjects
MAURITANIA; GENETIC variation; HEPATITIS B; HEPATITIS B virus; CHRONIC hepatitis B; CHRONIC active hepatitis; TOLL-like receptors
- Publication
BMC Infectious Diseases, 2024, Vol 24, Issue 1, p1
- ISSN
1471-2334
- Publication type
Article
- DOI
10.1186/s12879-024-09503-w