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- Title
Circulating irisin in healthy, young individuals: day-night rhythm, effects of food intake and exercise, and associations with gender, physical activity, diet, and body composition.
- Authors
Anastasilakis, Athanasios D; Polyzos, Stergios A; Saridakis, Zacharias G; Kynigopoulos, Georgios; Skouvaklidou, Elpida C; Molyvas, Dimitrios; Vasiloglou, Maria F; Apostolou, Aggeliki; Karagiozoglou-Lampoudi, Thomai; Siopi, Aikaterina; Mougios, Vassilis; Chatzistavridis, Panagiotis; Panagiotou, Grigorios; Filippaios, Andreas; Delaroudis, Sideris; Mantzoros, Christos S
- Abstract
<bold>Context: </bold>The myokine irisin may increase energy expenditure and affect metabolism.<bold>Objective: </bold>The objective of the study was to elucidate predictors of irisin and study whether circulating irisin may have day-night rhythm in humans.<bold>Design: </bold>This was an observational, cross-sectional study with an additional 24-hour prospective observational arm (day-night rhythm substudy) and two prospective interventional arms (mixed meal substudy and exercise substudy).<bold>Setting: </bold>The study was conducted at the Hellenic Military School of Medicine (Thessaloniki, Greece).<bold>Patients and Interventions: </bold>One hundred twenty-two healthy, young individuals were subjected to anthropometric and body composition measurements, and their eating and exercise behavior profiles were assessed with validated questionnaires. Subgroups were subjected to day-night rhythm, standardized meal ingestion, and 30-minute aerobic exercise studies.<bold>Main Outcome Measures: </bold>Circulating irisin levels were measured.<bold>Results: </bold>Ιrisin levels were lower in males than females (P = .02) after adjustment for lean body mass, which was its major determinant. Irisin levels followed a day-night rhythm (P < .001) with peak at 9:00 pm. Irisin levels were increased at the end of exercise (84.1 ± 10.0 vs 105.8 ± 14.3 ng/mL; P < .001). Irisin levels were not affected by intake of a standardized meal and were not associated with caloric intake or diet quality.<bold>Conclusions: </bold>In healthy, young individuals, circulating irisin displays a day-night rhythm, is correlated with lean body mass, and increases acutely after exercise.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2014, Vol 99, Issue 9, p3247
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2014-1367