We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Development of Green Differential Pulse Voltammetric Strategy for the Determination of Alfuzosin Hydrochloride at Pencil Graphite and Modified Carbon Paste Electrodes.
- Authors
Metias, Youstina Mekhail; Hussien, Emad Mohamed; Hosny, Mervat Mohamed; Ayad, Magda Mohamed
- Abstract
A sensitive and inexpensive differential pulse voltammetric technique was applied to investigate the electrochemical behavior of alfuzosin hydrochloride at two different working electrodes: silica gel modified carbon paste and pencil graphite electrodes (PGE). The voltammetric conditions were optimized using cyclic voltammetry, showing an irreversible anodic peak in Britton-Robinson buffered medium (pH 6) at 0.86-0.90 V. The electrochemical responses were linearly correlated with alfuzosin concentrations (R2 > 0.999) in the ranges of 0.6-20 and 0.3-20 µM, exhibiting higher electrocatalytic activity at PGE with a low detection limit/detectability of 0.099 µM. In addition, this study was a successful attempt for the drug determination in tablets and spiked urine samples with green profile evaluation, employing the National Environmental Methods Index, analytical Eco-Scale score, and Green Analytical Procedure Index.
- Subjects
CARBON electrodes; SUSTAINABLE development; GRAPHITE; CYCLIC voltammetry; DRUG tablets; PENCILS; SILICA gel
- Publication
Acta Chimica Slovenica, 2022, Vol 69, Issue 3, p507
- ISSN
1318-0207
- Publication type
Article
- DOI
10.17344/acsi.2022.7348