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- Title
Lifetime Exposure to Ambient Pollution and Lung Function in Children.
- Authors
Rice, Mary B.; Rifas-Shiman, Sheryl L.; Litonjua, Augusto A.; Oken, Emily; Gillman, Matthew W.; Kloog, Itai; Luttmann-Gibson, Heike; Zanobetti, Antonella; Coull, Brent A.; Schwartz, Joel; Koutrakis, Petros; Mittleman, Murray A.; Gold, Diane R.
- Abstract
<bold>Rationale: </bold>Few studies have examined associations between exposure to air pollution and childhood lung function after implementation of strict air quality regulations in the 1990s.<bold>Objectives: </bold>To assess traffic-related pollution exposure and childhood lung function.<bold>Methods: </bold>We geocoded addresses for 614 mother-child pairs enrolled during pregnancy in the Boston area 1999-2002 and followed them until a mid-childhood visit (median age, 7.7). We calculated the proximity of the home to the nearest major roadway. We estimated first year of life, lifetime, and prior-year exposure to particulate matter with a diameter smaller than 2.5 μm (PM2.5) by a hybrid model using satellite-derived aerosol optical depth, and to black carbon (BC) by a land-use regression model.<bold>Measurements and Main Results: </bold>Residential proximity to roadway and prior-year and lifetime PM2.5 and BC exposure were all associated with lower FVC. Associations with FEV1 were also negative and proportionally similar. Pollution exposures were not associated with the FEV1/FVC ratio or bronchodilator response. Compared with distances greater than or equal to 400 m, living less than 100 m from a major roadway was associated with lower FVC (-98.6 ml; -176.3 to -21.0). Each 2 μg/m(3) increment in prior-year PM2.5 was associated with lower FVC (-21.8 ml; -43.9 to 0.2) and higher odds of FEV1 less than 80% predicted (1.41; 1.03-1.93). Each 0.2 μg/m(3) increment in prior-year BC was associated with a 38.9 ml (-70.4 to -7.3) lower FVC.<bold>Conclusions: </bold>Estimates of long-term exposure to ambient pollution, including proximity to major roadway, PM2.5, and BC (a traffic-related PM2.5 constituent), were associated with lower lung function in this Boston-area cohort of children with relatively low pollution exposures.
- Subjects
AIR pollution; LONGITUDINAL method; LUNGS; RESEARCH funding; PULMONARY function tests; VITAL capacity (Respiration)
- Publication
American Journal of Respiratory & Critical Care Medicine, 2016, Vol 193, Issue 8, p881
- ISSN
1073-449X
- Publication type
journal article
- DOI
10.1164/rccm.201506-1058OC