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- Title
Olfactory exposure to males, including men, causes stress and related analgesia in rodents.
- Authors
Sorge, Robert E; Martin, Loren J; Isbester, Kelsey A; Sotocinal, Susana G; Rosen, Sarah; Tuttle, Alexander H; Wieskopf, Jeffrey S; Acland, Erinn L; Dokova, Anastassia; Kadoura, Basil; Leger, Philip; Mapplebeck, Josiane C S; McPhail, Martina; Delaney, Ada; Wigerblad, Gustaf; Schumann, Alan P; Quinn, Tammie; Frasnelli, Johannes; Svensson, Camilla I; Sternberg, Wendy F
- Abstract
We found that exposure of mice and rats to male but not female experimenters produces pain inhibition. Male-related stimuli induced a robust physiological stress response that results in stress-induced analgesia. This effect could be replicated with T-shirts worn by men, bedding material from gonadally intact and unfamiliar male mammals, and presentation of compounds secreted from the human axilla. Experimenter sex can thus affect apparent baseline responses in behavioral testing.
- Subjects
RODENT diseases; ANALGESIA; PHYSIOLOGICAL stress; AXILLA; ZYMOSAN; PLEXIGLASS; PSYCHOLOGY
- Publication
Nature Methods, 2014, Vol 11, Issue 6, p629
- ISSN
1548-7091
- Publication type
Article
- DOI
10.1038/nmeth.2935