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- Title
Molecular epidemiology of hydropericardium syndrome outbreakassociated serotype 4 fowl adenovirus isolates in central China.
- Authors
Teng Zhang; Qianyue Jin; Peiyang Ding; Yinbiao Wang; Yongxiao Chai; Yafei Li; Xiao Liu; Jun Luo; Gaiping Zhang
- Abstract
In several parts of China, there have been a large number of hydropericardium syndrome (HPS) outbreaks caused by serotype 4 fowl adenovirus (FAdV4) in broiler chickens since 2015. These outbreak-associated FAdV-4 strains were distinct from previous circulating strains which did not lead to severe HPS outbreaks. To better understand the molecular epidemiology of the currently circulating FAdV strains for effective diagnosis and treatment of HPS, we isolated 12 HPS outbreak-associated FAdV-4 strains from different regions in central China and investigated their molecular characteristics by performing phylogenetic analyses based on the hexon genes. Our results indicated the FAdV-4 strains in this study all belonged to serotype FAdV-4, species FAdV-C. And in comparison with ON1, KR5, MX-SHP95, PK-01, PJ-06 strains within the cluster where outbreak-associated FAdV-4 strains were located, the nucleotide sequence divergence were 1.31, 1.10, 1.42, 2.77 and 2.84%, respectively. Phylogenetic analyses revealed the hexon genes of the 12 outbreak-associated strains clustered to a relatively independent branch of the tree, and evolved from the same ancestor and we suggested that these outbreak-associated FAdV-4 strains originate from earlier strains in India.
- Subjects
CHINA; MOLECULAR epidemiology; SEROTYPES; ADENOVIRUSES; BROILER chicken diseases; PUBLIC health
- Publication
Virology Journal, 2016, Vol 13, Issue 1, p1
- ISSN
1743-422X
- Publication type
Article
- DOI
10.1186/s12985-016-0644-x