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- Title
Primary Thyroid Lymphoma: A Retrospective-Observational Study in a Single Institutional Center.
- Authors
Vita, Octavia; Dema, Alis; Barna, Robert; Cornea, Remus; Brebu, Dan; Vlad, Mihaela; Popa, Oana; Muntean, Ioana; Szilagyi, Diana; Iacob, Mihaela; Iordache, Maria; Cornianu, Marioara; Lazureanu, Dorela Codruta
- Abstract
Background and Objectives: primary thyroid lymphoma (PTL) is a rare neoplasm, displaying a variety of histological features. It is often a challenge for pathologists to diagnose this tumor. Materials and Methods: this study is a retrospective analysis of clinical and pathological characteristics of a group of eleven patients (eight women and three men, mean age 68 years, range 50–80 years) diagnosed with PTL. Results: nine patients (81.81%) presented a tumor with progressive growth in the anterior cervical region, usually painless and accompanied by local compressive signs. Histologically, we identified six cases (55%) of diffuse large B-cell lymphoma, three cases (27%) of extranodal marginal zone lymphoma, one case (9%) of follicular lymphoma, and one case (9%) of mixed follicular-diffuse lymphoma. PTL was associated with microscopic Hashimoto autoimmune thyroiditis in ten cases (90.9%). Ten patients (90.9%) presented with localized disease (stage I-IIE). A percentage of 60% of patients survived over 5 years. We observed an overall longer survival in patients under 70 years of age. Conclusions: PTL represents a diagnosis that needs to be taken into account, especially in women with a history of Hashimoto autoimmune thyroiditis, presenting a cervical tumor with progressive growth. PTL is a lymphoid neoplasia with favorable outcome, with relatively long survival if it is diagnosed at younger ages.
- Subjects
MUCOSA-associated lymphoid tissue lymphoma; DIFFUSE large B-cell lymphomas; LYMPHOMAS; AUTOIMMUNE thyroiditis; FOLLICULAR lymphoma; THYROID gland
- Publication
Medicina (1010660X), 2024, Vol 60, Issue 3, p476
- ISSN
1010-660X
- Publication type
Article
- DOI
10.3390/medicina60030476