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- Title
Changing profile of rotavirus genotypes in Bangladesh, 2006-2012.
- Authors
Afrad, Mokibul Hassan; Hassan, Zahid; Farjana, Saiada; Moni, Sayra; Barua, Subarna; Das, Sumon Kumar; Faruque, Abu Syed Golam; Azim, Tasnim; Rahman, Mustafizur
- Abstract
<bold>Background: </bold>Rotavirus is the leading cause of severe diarrhea in infants and young children worldwide including Bangladesh. Unlike what was seen in high-income countries, the licensed rotavirus vaccines did not show high efficacy in Bangladeshi trials. We assessed rotavirus prevalence and genotypes in Bangladesh over six-year period to provide baseline information on the rotavirus burden and changing profile in the country.<bold>Methods: </bold>This study was conducted from June 2006 to May 2012 in Matlab, Bangladesh. Group A rotaviruses were detected in stools collected from diarrhea patients by ELISA and genotyped using multiplex reverse transcription PCR followed by nucleotide sequencing.<bold>Results: </bold>Of the 9678 stool samples, 20.3% were positive for rotavirus. The most predominant genotype was G1P[8] (22.4%), followed by G9P[8] (20.8%), G2P[4] (16.9%) and G12P[8] (10.4%). Mixed infections were detected in 14.2% of the samples. Emergence of an unusual strain, G9P[4] was documented during 2011-12. Several amino acid mismatches in the antigenic epitopes of VP7 and VP4 between Bangladeshi and the vaccine strains were identified.<bold>Conclusions: </bold>Our study provides important information on rotavirus genotypes that should be considered for the selection and introduction of rotavirus vaccines in Bangladesh.
- Publication
BMC Infectious Diseases, 2013, Vol 13, Issue 1, p320
- ISSN
1471-2334
- Publication type
journal article
- DOI
10.1186/1471-2334-13-320