We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hyperbaric oxygen alleviates the activation of NLRP‑3‑inflammasomes in traumatic brain injury.
- Authors
HUIHUI QIAN; QINGHE LI; WODA SHI
- Abstract
Growing evidence has demonstrated that the nucleotide‑binding oligomerization domain‑like receptor family pyrin domain containing 3 (NLRP‑3) inflammasome‑mediated inflammatory pathways have been involved in the secondary injury of traumatic brain injury (TBI). In the present study, the authors investigated the effects of hyperbaric oxygen (HBO) therapy on the NLRP‑3 inflammasome pathway following TBI. Following the evaluation of motor deficits and brain edema, the therapeutic effects of HBO on interleukin (IL)‑1β and IL‑18 expression were assessed, as well as NLRP‑3 inflammasome activation following TBI. HBO may improve motor score and reduce brain edema, accompanied with the reduction of IL‑1β and IL‑18 during the 7‑day observation period. Furthermore, HBO suppressed mRNA and protein expression of NLRP‑3‑inflammasome components, especially reducing NLRP‑3 expression in microglia. Thus, these results suggested that HBO alleviates the inflammatory response in experimental TBI via modulating microglial NLRP‑3‑inflammasome signaling.
- Subjects
BRAIN injury treatment; CENTRAL nervous system; BRAIN concussion; BRAIN tumors; NEURODEGENERATION
- Publication
Molecular Medicine Reports, 2017, Vol 16, Issue 4, p3922
- ISSN
1791-2997
- Publication type
Article
- DOI
10.3892/mmr.2017.7079