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- Title
Uterine disorders and pregnancy complications: insights from mouse models.
- Authors
Hyunjung Jade Lim; Haibin Wang; Lim, Hyunjung Jade; Wang, Haibin
- Abstract
Much of our knowledge of human uterine physiology and pathology has been extrapolated from the study of diverse animal models, as there is no ideal system for studying human uterine biology in vitro. Although it remains debatable whether mouse models are the most suitable system for investigating human uterine function(s), gene-manipulated mice are considered by many the most useful tool for mechanistic analysis, and numerous studies have identified many similarities in female reproduction between the two species. This Review brings together information from studies using animal models, in particular mouse models, that shed light on normal and pathologic aspects of uterine biology and pregnancy complications.
- Subjects
UTERUS physiology; PREGNANCY complications; PATHOLOGICAL physiology; PREVENTIVE medicine; ANIMAL models in research; FEMALE reproductive organs; EMBRYONIC physiology; ENDOMETRIUM physiology; BIOLOGICAL models; ENDOMETRIOSIS; RESEARCH; ANIMAL experimentation; MISCARRIAGE; RESEARCH methodology; UTERINE diseases; FETAL growth retardation; MEDICAL cooperation; EVALUATION research; CELL cycle; COMPARATIVE studies; ECTOPIC pregnancy; MICE
- Publication
Journal of Clinical Investigation, 2010, Vol 120, Issue 4, p1004
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI41210