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- Title
Metal-Free [2+2+2] Cycloaddition of Ynamides and Nitriles: Mild and Regioselective Synthesis of Fully Substituted Pyridines.
- Authors
Wang, Yong; Song, Li ‐ Juan; Zhang, Xinhao; Sun, Jianwei
- Abstract
A metal-free trimolecular [2+2+2] cycloaddition of internal ynamides and nitriles for de novo synthesis of fully substituted pyridines is disclosed. With the versatile Brønsted acid catalyst HNTf2, the mild intermolecular cyclotrimerization process proceeds with complementary chemoselectivity and excellent regioselectivity.
- Subjects
RING formation (Chemistry); YNAMIDES; NITRILE synthesis; PYRIDINE; CHEMOSELECTIVITY; REGIOSELECTIVITY (Chemistry)
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 33, p9856
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201603889