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- Title
Construction of Quaternary Stereogenic Carbon Centers through Copper-Catalyzed Enantioselective Allylic Alkylation of Azoles.
- Authors
Ohmiya, Hirohisa; Zhang, Heng; Shibata, Saori; Harada, Ayumi; Sawamura, Masaya
- Abstract
Copper-catalyzed enantioselective allylic alkylation of azoles with γ,γ-disubstituted primary allylic phosphates was achieved using a new chiral N-heterocyclic carbene ligand bearing a naphtholic hydroxy group. This reaction occurred with excellent branch regioselectivity and high enantioselectivity, thus forming a controlled all-carbon quaternary stereogenic center at the position α to the heteroaromatic ring.
- Subjects
MOLECULAR structure of azoles; QUATERNARY structure; ENANTIOSELECTIVE catalysis; ALLYLIC alkylation; REGIOSELECTIVITY (Chemistry); COPPER catalysts
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 15, p4855
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201600619