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- Title
Copper-Catalyzed Stereoselective Aminoboration of Bicyclic Alkenes.
- Authors
Sakae, Ryosuke; Hirano, Koji; Satoh, Tetsuya; Miura, Masahiro
- Abstract
A copper-catalyzed aminoboration of bicyclic alkenes, including oxa- and azabenzonorbornadienes, has been developed. With this method, amine and boron moieties are simultaneously introduced at an olefin with exo selectivity. Subsequent stereospecific transformations of the boryl group can provide oxygen- and nitrogen-rich cyclic molecules with motifs that may be found in natural products or pharmaceutically active compounds. Moreover, a catalytic asymmetric variant of this transformation was realized by using a copper complex with a chiral bisphosphine ligand, namely ( R, R)-Ph-BPE.
- Subjects
TRANSITION metals; BRASS sculpture; COPPER glazes; CUMULATIVE double bonds; ALKENE photodimerization
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 2, p623
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201409104