We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Combustion Synthesis of Functionalized Carbonated Boron Nitride Nanoparticles and Their Potential Application in Boron Neutron Capture Therapy.
- Authors
Cudziło, Stanisław; Szermer-Olearnik, Bożena; Dyjak, Sławomir; Gratzke, Mateusz; Sobczak, Kamil; Wróblewska, Anna; Szczygieł, Agnieszka; Mierzejewska, Jagoda; Węgierek-Ciura, Katarzyna; Rapak, Andrzej; Żeliszewska, Paulina; Kozień, Dawid; Pędzich, Zbigniew; Pajtasz-Piasecka, Elżbieta
- Abstract
In this research, we developed boron-rich nanoparticles that can be used for boron neutron capture therapy as potential carriers for boron delivery to cancerous tissues. Functionalized carbonated boron nitride nanostructures (CBNs) were successfully synthesized in self-propagating combustion waves in mixtures of high-nitrogen explosives and boron compounds. The products' composition, morphology, and structural features were investigated using Fourier transform infrared spectroscopy, powder X-ray diffraction, low-temperature nitrogen sorption analysis, thermogravimetric analysis, high-resolution scanning electron microscopy, and high-resolution transmission electron microscopy. The extreme conditions prevailing in combustion waves favor the formation of nanosized CBN hollow grains with highly disordered structures that are properly functionalized on the surface and inside the particles. Therefore, they are characterized by high porosity and good dispersibility in water, which are necessary for medical applications. During biological tests, a concentration-dependent effect of the obtained boron nitride preparations on the viability of normal and neoplastic cells was demonstrated. Moreover, the assessment of the degree of binding of fluorescently labeled nanoparticles to selected cells confirmed the relationships between the cell types and the concentration of the preparation at different incubation time points.
- Subjects
BORON-neutron capture therapy; NEUTRON capture; SELF-propagating high-temperature synthesis; FOURIER transform infrared spectroscopy; X-ray powder diffraction; NANOPARTICLES; NANOCARRIERS; BORON nitride
- Publication
Materials (1996-1944), 2024, Vol 17, Issue 10, p2438
- ISSN
1996-1944
- Publication type
Article
- DOI
10.3390/ma17102438