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- Title
A Versatile Approach to CF<sub>3</sub>-Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors.
- Authors
Mateu, Natalia; Ciordia, Myriam; Delgado, Oscar; Sánchez ‐ Roselló, María; Trabanco, Andrés A.; Van Gool, Michiel; Tresadern, Gary; Pérez ‐ Benito, Laura; Fustero, Santos
- Abstract
The groups of Santos Fustero at the University of Valencia (Spain) and Oscar Delgado at Janssen Research and Development (Spain) have been invited for the front cover of this issue. The image depicts the docking of one of the β-secretase 1 (BACE1) inhibitors encapsulated in a sketch of the human brain. Read the full text of the article at .
- Subjects
ALZHEIMER'S disease treatment; SECRETASE inhibitors; AMIDINES
- Publication
Chemistry - A European Journal, 2015, Vol 21, Issue 33, p11617
- ISSN
0947-6539
- Publication type
Other
- DOI
10.1002/chem.201502483