We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impact of ZrO 2 Content on the Formation of Sr-Enriched Phosphates in Al 2 O 3 /ZrO 2 Nanocomposites for Bone Tissue Engineering.
- Authors
Nunes, Fabio Caixeta; Santos, Sarah Ingrid Pinto; Colnago, Luiz Alberto; Hammer, Peter; Ferreira, Julieta Adriana; Ambrósio, Carlos Eduardo; Pallone, Eliria Maria Jesus Agnolon
- Abstract
This study investigates the profound impact of the ZrO2 inclusion volume on the characteristics of Al2O3/ZrO2 nanocomposites, particularly influencing the formation of calcium phosphates on the surface. This research, aimed at advancing tissue engineering, prepared nanocomposites with 5, 10, and 15 vol% ZrO2, subjecting them to chemical surface treatment for enhanced calcium phosphate deposition sites. Biomimetic coating with Sr-enriched simulated body fluid (SBF) further enhanced the bioactivity of nanocomposites. While the ZrO2 concentration heightened the oxygen availability on nanocomposite surfaces, the quantity of Sr-containing phosphate was comparatively less influenced than the formation of calcium phosphate phases. Notably, the coated nanocomposites exhibited a high cell viability and no toxicity, signifying their potential in bone tissue engineering. Overall, these findings contribute to the development of regenerative biomaterials, holding promise for enhancing bone regeneration therapies.
- Subjects
ALUMINUM oxide; TISSUE engineering; STRONTIUM; NANOCOMPOSITE materials; BIOACTIVE glasses; CALCIUM phosphate; SURFACE preparation; BONE regeneration
- Publication
Materials (1996-1944), 2024, Vol 17, Issue 8, p1893
- ISSN
1996-1944
- Publication type
Article
- DOI
10.3390/ma17081893