We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Ultrafast Electrochemical Trigger Drug Delivery Mechanism for Nanographene Micromachines.
- Authors
Khezri, Bahareh; Beladi Mousavi, Seyyed Mohsen; Krejčová, Ludmila; Heger, Zbyněk; Sofer, Zdeněk; Pumera, Martin
- Abstract
Nano/micromachines with autonomous motion are the frontier of nanotechnology and nanomaterial research. These self‐propelled nano/micromachines convert chemical energy obtained from their surroundings to propulsion. They have shown great potential in diagnostic and therapeutic applications. This work introduces a high‐speed tubular electrically conductive micromachine based on reduced nanographene oxide (n‐rGO) as a platform for drug delivery and platinum (Pt) as the catalytic inner layer. n‐rGO/Pt micromachines are loaded with doxorubicin (DOX) by a simple physical adsorption with a very high loading efficiency, displaying single‐ or multistrand wrapping of DOX monomers on the micromachine cylinders. More importantly, it is found that electron injection into DOX@n‐rGO/Pt micromachines via electrochemistry leads to expulsion of DOX from micromachines in motion within only a few seconds. An in vitro study confirms this efficient release mechanism in the presence of cancerous cells. The unique properties of the n‐rGO/Pt micromotor enable the effective management of DOX release at the tumor site and thus enhances the therapeutic efficiency and reduces the side toxicity toward the healthy tissue. These micromachine drug carriers combine the high loading capacity of conventional carbon‐based drug carriers with a fast and efficient electrochemical drug‐release mechanism. An active platform for an electrochemically triggered drug delivery system based on microrobots is demonstrated. Graphene‐based micromachines are loaded with doxorubicin (DOX). Their ability to deliver an anticancer drug is demonstrated in combination with an on‐demand electrochemical release method. The electron injection into micromachines leads to the controlled release of DOX from micromachines in motion within only a few seconds.
- Subjects
DRUG delivery systems; ELECTROCHEMISTRY; GRAPHENE; MICROELECTROMECHANICAL systems; CHEMICAL energy conversion
- Publication
Advanced Functional Materials, 2019, Vol 29, Issue 4, pN.PAG
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.201806696