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- Title
Detailed role of microRNA‐mediated regulation of PI3K/AKT axis in human tumors.
- Authors
Al‐Hawary, Sulieman Ibraheem Shelash; Ruzibakieva, Malika; Gupta, Reena; Malviya, Jitendra; Toama, Mariam Alaa; Hjazi, Ahmed; Alkhayyat, Murtadha Raad Radhi; Alsaab, Hashem O.; Hadi, Ali; Alwaily, Enas R.
- Abstract
The regulation of signal transmission and biological processes, such as cell proliferation, apoptosis, metabolism, migration, and angiogenesis are greatly influenced by the PI3K/AKT signaling pathway. Highly conserved endogenous non‐protein‐coding RNAs known as microRNAs (miRNAs) have the ability to regulate gene expression by inhibiting mRNA translation or mRNA degradation. MiRNAs serve key role in PI3K/AKT pathway as upstream or downstream target, and aberrant activation of this pathway contributes to the development of cancers. A growing body of research shows that miRNAs can control the PI3K/AKT pathway to control the biological processes within cells. The expression of genes linked to cancers can be controlled by the miRNA/PI3K/AKT axis, which in turn controls the development of cancer. There is also a strong correlation between the expression of miRNAs linked to the PI3K/AKT pathway and numerous clinical traits. Moreover, PI3K/AKT pathway‐associated miRNAs are potential biomarkers for cancer diagnosis, therapy, and prognostic evaluation. The role and clinical applications of the PI3K/AKT pathway and miRNA/PI3K/AKT axis in the emergence of cancers are reviewed in this article. Significance statement: By suppressing apoptosis, oxidative stress, and a variety of downstream molecules, the PI3K/AKT signaling pathway is essential for the beginning and development of many cancer illnesses. The PI3K/AKT pathway is related to numerous other pathways. Additionally, a growing body of recent research has demonstrated the reciprocal interactions between this signaling pathway and microRNAs, a huge group of small noncoding RNAs. The link between various miRNAs and significant components of the PI3K/AKT/mTOR signaling pathway, as well as their significance in cancer biology, were thus explored in this review.
- Subjects
PI3K/AKT pathway; GENE expression; NON-coding RNA; CELLULAR signal transduction; TUMOR markers
- Publication
Cell Biochemistry & Function, 2024, Vol 42, Issue 1, p1
- ISSN
0263-6484
- Publication type
Article
- DOI
10.1002/cbf.3904