We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A systematic review of the epidemiological literature on the risk of urological cancers in systemic lupus erythematosus.
- Authors
Huang, Hou-bao; Jiang, Shu-chuan; Han, Jie; Cheng, Qing-shui; Dong, Chang-bin; Pan, Cai-ming
- Abstract
Purpose: A grow body of studies has evaluated the risk of development of urological cancer in systemic lupus erythematosus (SLE) with inconclusive results. To clarify the association, a meta-analysis approach was performed to assess the published evidence on urological cancers and SLE. Methods: Relevant English electronic databases were systematic searched for published studies characterizing the risk of developing urological cancer as a result of SLE. Standardized incidence rate (SIR) with its 95 % confidence interval (CI) of each study was combined using a fixed-/random-effect model in STATA software. Results: A total of 12 papers including 68366 SLE patients were suitable for meta-analysis. Of these, 9 reported the SIR for prostate cancer, 7 for bladder cancer and 6 for kidney cancer. Summary SIRs were 0.77 (95 % CI 0.69-0.87, P < 0.001); 1.75 (95 % CI 0.94-3.23, P = 0.075) and 2.29 (95 % CI 1.25-4.18, P = 0.007), respectively. Significant heterogeneity was noticed in subgroups of bladder and kidney cancer. No obvious publication bias was detected. Conclusions: Findings from this meta-analysis indicate that SLE is associated with a decreased risk of prostate cancer and an increased risk of kidney cancer.
- Subjects
CANCER risk factors; URINARY organ cancer; SYSTEMIC lupus erythematosus; SYSTEMATIC reviews; MEDICAL literature; EPIDEMIOLOGY; MEDICAL publishing; META-analysis
- Publication
Journal of Cancer Research & Clinical Oncology, 2014, Vol 140, Issue 7, p1067
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-014-1604-8