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- Title
Elevated PRL-3 expression was more frequently detected in the large primary gastric cancer and exhibits a poor prognostic impact on the patients.
- Authors
Zhao Wang; Shi-Rong Cai; Yu-Long He; Wen-Hua Zhan; Chang-Hua Zhang; Hui Wu; Jian-Jun Peng; Jian-Bo Xu; Xin-Hua Zhang; Liang Wang; Wu Song
- Abstract
It has been reported that elevated PRL-3 expression was closely associated with lymph node metastasis of gastric cancer. In the present study, we detected the expression of PRL-3 in primary gastric cancer tissue, and evaluated its prognostic impact on the patients. Total 137 gastric tumor samples were measured for PRL-3 phosphatase expression using immunohistochemistry method, and the overall survival rate was compared between the patients with high PRL-3 expression ( n = 85) and those with moderate or low PRL-3 expression ( n = 52) in the primary tumor. PRL-3 expression was more frequently detected in the tumors with a diameter >40 mm and in advanced stages (TNM stage III or IV). Furthermore, the overall survival rate of the patients with high expression of PRL-3 in the primary tumor was significantly less than those with moderate or low expression ( P < 0.001). PRL-3 expression is associated with gastric cancer progression. Its high expression in the primary lesion had a negative impact on the prognosis of the patients. This strongly suggests that PRL-3 should be considered as a prognostic factor.
- Subjects
CANCER patients; CANCER invasiveness; LYMPH nodes; IMMUNOHISTOCHEMISTRY; TUMORS
- Publication
Journal of Cancer Research & Clinical Oncology, 2009, Vol 135, Issue 8, p1041
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-008-0541-9