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- Title
N-Acetylcysteine prevents baker's-yeast-induced inflammation and fever.
- Authors
Ferreira, Ana; Pasin, Juliana; Saraiva, André; Ratzlaff, Viviane; Rossato, Mateus; Andrighetto, Rosália; Rubin, Maribel; Ferreira, Juliano; Mello, Carlos
- Abstract
Objetive and design: To investigate whether N-acetylcysteine (NAC) alters baker's-yeast-induced fever and inflammation. Material or subjects: Male Wistar rats (26-28 days old) injected with baker's yeast (135 mg/kg, intraperitoneal) or prostaglandin E (300 ng/100 μL, intrathecal). Treatment: Rats were injected with NAC (500 mg/kg, subcutaneous, or 50 μg/100 μL, intrathecal) 1 h before, or 2 h after, pyrogen injection. Methods: Rectal temperature changes induced by baker's yeast, PGE and NAC were followed up over time. Four hours after baker's yeast injection, total leukocytes, protein, interleukin (IL)-1β, tumor necrosis factor (TNF)-α and nonprotein thiol content were assessed in peritoneal lavage and hypothalamus. Results: Systemic administration of NAC decreased leukocytes, protein, IL-1β and TNF-α levels in peritoneal lavage, and decreased IL-1β levels in the hypothalamus. The central administration of NAC prevented baker's-yeast-induced fever, but did not alter the febrile response elicited by prostaglandin E. Conclusion: These results suggest an anti-inflammatory and antipyretic role for NAC in yeast-induced peritonitis.
- Subjects
CYTOKINES; FEVER; LEUCOCYTE motility; ACETYLCYSTEINE; INFLAMMATION; SACCHAROMYCES cerevisiae
- Publication
Inflammation Research, 2012, Vol 61, Issue 2, p103
- ISSN
1023-3830
- Publication type
Article
- DOI
10.1007/s00011-011-0392-8