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- Title
MULTIMODAL HUMAN BRAIN LONGITUDINAL PARCELLATION ACROSS LIFESPAN.
- Authors
YAN, JUNYI; YANG, JINZHU; ZHAO, DAZHE
- Abstract
Subdividing the human brain into several functionally distinct and spatially contiguous areas is important to understand the amazingly complex human cerebral cortex. However, adult aging is related to differences in the structure, function, and connectivity of brain areas, so that the single population subdivision does not apply to multiple age groups. Moreover, different modalities could provide affirmative and complementary information for the human brain subdivision. To obtain a more reasonable subdivision of the cerebral cortex, we make use of multimodal information to subdivide the human cerebral cortex across lifespan. Specifically, we first construct a population average functional connectivity matrix for each modality of each age group. Second, we separately calculate the population average similarity matrix for the cortical thickness and myelin modality of each age group. Finally, we fuse these population average matrixes to obtain the multimodal similarity matrix and feed it into the spectral clustering algorithm to generate the brain parcellation for each age group.
- Subjects
CEREBRAL cortex; AGE groups; FUNCTIONAL connectivity; HUMAN beings; MYELIN
- Publication
Journal of Mechanics in Medicine & Biology, 2021, Vol 21, Issue 10, p1
- ISSN
0219-5194
- Publication type
Article
- DOI
10.1142/S0219519421400595